Background: To compare the efficacy and safety of timolol 0.5% versus brinzolamide 1.0% when added to travoprost monotherapy in patients with primary open-angle glaucoma or ocular hypertension. Group (closed) – BA Erziehungswissenschaften, Uni Mainz. mail.uni-mainz.de links to network IP address 134.93.178.3. report that competitive mechanisms are required to correctly partition synaptic inputs from different transmitter systems on the dendritic arbor of a Drosophila motoneuron. J Exp Biol 202:3555-3564. Duch C, Mentel T (2003) Motoneuron terminal retraction and outgrowth depend on stage-specific activity patterns during the metamorphosis of Manduca sexta. Int Comp Biol 46:E36. Acta Biol Hung 55:3-12. Mar 19;12:5. doi: 10.3389/fnsys.2018.00005. Aging (Albany NY). : +49 (0) 6131 / 39 - 21979 Fax: +49 (0) 6131 / 39 - 23 004. J Exp Biol 198:1963-1976. Front Syst Neurosci 11:68, Kadas D, Klein A, Krick N, Worrell JW, Ryglewski S, Duch C (2017) Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion. Ryglewski S, Duch C, Altenhein B (2017) Tyramine Actions on Drosophila Flight Behavior Are Affected by a Glial Dehydrogenase/Reductase. Synapses determine information processing between neurons, whereas electrical properties as well as structure determine information processing within neurons. Morris OT, Duch C, Stevenson PA (1999) Reflex activation of locust octopaminergic modulatory neurons by proprioreceptors responsive to flight muscle contractions. J Neurosci 27(41):11122-31. J Comp Neurol 422:1-17. (2018) Structural and Molecular Properties of Insect Type II Motor Axon Terminals. E-Mail. J Neurophysiol 79:361-370. Prof. Dr. Carsten Duch. Brain Res Bulletin 53:571-583. (3)Institute of Developmental Biology and Neurobiology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany; ryglewsk@uni-mainz.de cduch@uni-mainz.de. Libersat F, Duch C (2004) Cellular and molecular mechanisms of the maturation of neuronal dendritic trees. Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany. Mainz, Renânia-Palatinado, Alemanha: Presidente Georg Krausch Total de estudantes: 37 039 Página oficial website oficial: A Universidade Johannes Gutenberg de Mainz (em alemão: Johannes Gutenberg-Universität Mainz) é uma instituição de ensino superior localizada em Mainz, no estado da Renânia-Palatinado, Alemanha. Mit Erfahrungsberichten, NC-Liste und zulassungsfreien Studiengängen. 1. Johannes Gutenberg-Universität Mainz Jakob-Welder-Weg 9 55099 Mainz. Therefore, even with a complete connectome in hand, understanding brain function requires an intricate analysis of the physiology and functional morphology of its component neurons. Vonhoff F, Williams A, Ryglewski S, Duch C (2012) Drosophila as a Model for MeCP2 Gain of Function in Neurons. Ryglewski S, Vonhoff F, Scheckel K, Duch C (2017) Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material. Duch C, Pflueger HJ (1995) Motor patterns for horizontal and upside down walking and vertical climbing in the locust. Lukas Kilo, Ph.D. Student, kilo@uni-mainz.de Die rechteckige Kernburg ist von vier Gebäudeflügeln und einer Schildmauer mit Ecktürmen umgeben. Duch C, Pflueger HJ (1999) DUM neurons in locust flight: a model system for amine mediated peripheral adjustments to a central motor program. Evers JF, Muench D, Duch C (2006) Developmental relocation of presynaptic terminals along distinct types of dendritic filopodia. Mainz [1] [2] [3] ou Mogúncia [4] [5] (em alemão: Mainz, em latim: Mogontiacum, em francês: Mayence) é uma cidade da Alemanha, capital do estado federal de Renânia-Palatinado. To address these questions we use Drosophila melanogaster as a model system. Methods: Patients meeting selection criteria (IOP one eye 19 mmHg and ≤32 mmHg and IOP both eyes ≤32 mmHg at 8:00 h) were switched to travoprost monotherapy for 4 weeks. J Comput Neurosci 34(2):211-29. Kadas D, Duch C, Consoulas C. (2019) Postnatal Increases in Axonal Conduction Velocity of an Identified Drosophila Interneuron Require Fast Sodium, L-Type Calcium and Shaker Potassium Channels. 9.00-12.00) Tel. E-Mail: joerg.korff@uni-mainz… Meseke M, Evers JF, Duch C (2009) Postembryonic dendritic remodeling of an identified neuron is accompanied by changes in synapse distribution and dendritic input computation. Duch C, Vonhoff F, Ryglewski S (2008) Dendrite elongation and dendritic branching are affected separately by different forms of intrinsic motoneuron excitability. Physiology (Bethesda) 26:293-303. Die spätstaufische Burg der Erzbischöfe und Kurfürsten von Mainz wurde um das Jahr 1245 zum Schutz des Gebiets an der Lahnmündung erbaut. J Neurosci 15:1109-1113. The promotion and introduction of new ideas, the use of knowledge to improve people’s lives and encourage them to overcome the many boundaries they encounter daily – these are the underlying ambitions of Johannes Gutenberg University Mainz. Current project. Brembs B, Christiansen F, Pflueger HJ, Duch C (2007) Flight initiation and maintenance deficits in flies with genetically altered biogenic amine levels. PLoS One, 7(2):e31835. Additional information about this page. Perturbations cause dendrite shifts and result in defects of adaptive motor control. Vonhoff F, Duch C (2010) Tiling Among Stereotyped Dendritic Branches in an Identified Drosophila Motoneuron. Cell Tissue Res 325:175-87. Page-Name:IDN Homepage Last Update:12.October 2017 Accordingly, dendritic defects are consistent anatomical correlates of numerous brain diseases, but specific causality remains unproven. Duch C 2 Affiliations . However, in a computing, adapting, and learning system such as the brain, these properties must also retain functional plasticity. Adrenergic signaling profoundly modulates animal behavior. PLoS Biol 5(4):e66. In addition to the unprecedented genetic tools available in Drosophila, the transformation from the larval to the adult stage during metamorphosis is a striking example of postembryonic nervous system plasticity and remodeling, and the functions of individually identified neurons can directly be related to stage specific behaviors. Neurons are the building blocks of the brain. Cell Tissue Res 334:477-498. Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and membrane currents. Die Entfernung von Graffiti kostet die Johannes Gutenberg-Universität jährlich rund 80.000 Euro. Neurobiol of Disease, in press. Börner J, Duch C (2010) A standard neuroanatomy atlas for the adult Drosophila ventral nerve cord. Fields L, Duch C, Pflueger HJ (2007) Reflex activation of octopaminergic unpaired median neurons in the locust. J Comp Physiol A: 195(3):265-77. Williams AA, White R, Sniard A, Corneveaux J, Huentelman M, Duch C (2016) MECP2 impairs neuronal structure by regulating KIBRA. Kühn C, Duch C (2013) Putative Excitatory and Putative Inhibitory Inputs Localize to Different Dendritic Domains in a Drosophila Flight Motoneuron. Wären Kameras an besonders betroffenen Stellen … Somos uma instituição de Educação que atua nas áreas de Treinamento em Desenvolvimento Profissional e Gerencial desde fevereiro de 2003. and the secretary: Renate Bertgen. Duch C, Levine RB (2000) Remodeling of membrane properties and dendritic architecture accompany the postembryonic conversion of a ‘slow’ into a ‘fast’ motoneuron. Kuehn C, Duch C (2008) Expression of two different isoforms of fasciclin II during postembryonic central nervous system remodeling in Manduca sexta. Group leader. DEGREE COURSE: Guide to the Bachelors and Masters Degree Programs Logo der Johannes Gutenberg-Universität Mainz, Zusätzliche Informationen zu dieser Seite. Burg Lahneck. J Neurophysiol 102:41-58. Duch C, Mentel T (2004) Activity affects dendritic shape and synapse elimination during steroid induced dendritic regression in Manduca sexta. J Comp Neurol, 518:2169-2185. Fax +49 6131 39-25548. 55099 Mainz Germany. Neuroimage 23:1283-1298. Corresponding Author. When analyzing the role of dendrites, the experimental challenge is to abolish them selectively in identified Drosophila wing motoneurons without affecting other properties of these specific neurons or others. J Neurosci 24:9826-9837. Homepage. Vierk R, Pflueger HJ, Duch C (2009) Differential effects of octopamine and tyramine on the central pattern generator for Manduca flight. Development 140(3):606-16. Evers JF, Schmitt S, Scholz M, Duch C (2005) New frontiers in functional neuroanatomy: precise automatic reconstruction from confocal image stacks. Consoulas C, Duch C, Bayline RJ, Levine RB (2000) Behavioral transformations during metamorphosis: remodeling of neural and motor systems. J Neurophysiol 87:1415-1425. Eur J Neurosci, 37(6):860-75. Börner J , Puschmann T, Duch C (2006) A steroid hormone affects sodium channel expression in Manduca central neurons. (2)Institute of Molecular Biology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany. Arbeitsgruppe von der Theorie zur Forschungspraxis. J Neurosci 34(5):1924-31. Biogenic amines, like norepinephrine, can act as neuromodulators to render animal behavior adaptive to changing external and internal conditions. The Ernst Florey memory lecture. J Neurosci 20:6950-6961. mail.uni-mainz.de uses Microsoft HTTPAPI web technologies. eBook - JaSeAn. Exkursion LL BiMA. Please note: Due to the amount of requests reaching the “Studierendenservice” at the moment there is a delay up to one week in answering them. Biozentrum 1 Hanns-Dieter-Hüsch-Weg 15, 2nd Floor, Room 02.352 55128 Mainz Tel: +49 6131/3923419 Fax: +49 6131/3925443 e-mail: cduch@uni-mainz.de. Hohensee S, Bleiss W, Duch C (2008) Correlative electron and confocal microscopy assessment of synapse localization in the central nervous system of an insect. We are interested in the functional diversity of voltage gated calcium channels and its implications for normal neurophysiology ans behavior. Pflueger HJ, Duch C, Heidel E (2004) Neuromodulatory octopaminergic neurons and their functions during insect motor behaviour. Ryglewski S, Kadas S, Hutchinson K, Schuetzler N, Vonhoff F, Duch C (2014) Dendrites are dispensable for basic motoneuron function but essential for fine tuning of behavior. J Neurosci 37(45):10971-10982. Pflueger HJ, Duch C (2000) The functional role for octopaminergic neurons in insect motor behavior. Besucheranschrift / Office: Hanns-Dieter-Hüsch-Weg 15 (Gebäude 1578, 2.Stock, 02-352) 55128 Mainz 11(6):1850-1873. doi: 10.18632/aging.101880. Close affiliations . Duch's work group at Mainz University is investigating dendritic structures and functions using the fruit fly Drosophila as a model organism. J Vis Exp 15;(68). Dev Biol 231:348-363. To understand the adaptive regulation of these properties our research objectives are: • identify the molecular mechanisms that regulate electrical and morphological properties of neurons. Unravel Resilience - Using Multi-Omics Integration to explore the Molecular Background of Stress Resilience Resilience is the ability to cope with stress or to quickly recover to pre-crisis state after being exposed to extreme stress. J Neurophysiol 93:2331-2342. Proceedings of the National Academy of … Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and … Duch C, Mentel T, Pflueger HJ (1999) Distribution and activation of different types of octopaminergic DUM neurons in the locust. Kadas D, Ryglewski S, Duch C (2015) Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion. J Insect Physiol 54(1):240-54. Arbeitsgruppe/Research team Prof. Dr. C. Duch. J Neurophysiol 102(6):3673-88. J Comp Neurol 403:119-134. Dev Biol 297(1):214-227. Mentel T, Duch C, Müller U, Stypa H, Wegener G, Pflueger HJ (2003) Fuel selection in locust flight muscle by the activity of central modulatory neurons. Cell Biology, JGU Mainz: Albrecht Clement Inst. Vierk R, Pflueger HJ, Duch C (2010) Postembryonic development of centrally generated flight motor patterns in the hawkmoth, Manduca sexta. J Neurophysiol 100(5):2525-36. Kathryn Scheckel, Carsten Duch Correspondence cduch@uni-mainz.de In Brief Ryglewski et al. J Comp Neurol, 518:2437-2455. J Comp Neurol 450:153-166. Eur J Neurosci 23:335-349. Approximately 100 billion neurons in our brain form 100 trillion synapses onto 100,000 miles of dendritic cable. Institute of Neurobiology, Johannes Gutenberg University of Mainz, Mainz, Germany. Neurons are the building blocks of the brain. Find more data about mail. eCollection 2018. We use the versatile genetic model system Drosophila melanogaster for our research. Duch, Univ.-Prof. Dr. Carsten Address: Hanns-Dieter-Hüsch-Weg 15,55128 Mainz Building: BioZentrum I (1578) Room: 02-352 Phone: +49 6131 39 23419 • determine the functional consequences of correct and false regulation of neuronal properties for synaptic integration, neuronal firing patterns, and behavior in the healthy and in the diseased brain. doi: 10.1523/ENEURO.0181-19.2019. PNAS 111(50):18049-54. 1990-1994 Study of Biology, Free University Berlin 1994 Diploma of Biology, Free University Berlin 1995-1998 PhD Student at the Institute of Neurobiology, Free University Berlin Stocker B, Bochow C, Damrau C, Mathejczyk T, Wolfenberg H, Colomb J, Weber C, Ramesh N, Duch C, Biserova NM, Sigrist S, Pflüger HJ. Email: cduch@uni-mainz.de Search for more papers by this author Meseke M, Evers JF, Duch C (2009) PTX-induced hyperexcitability affects dendritic shape and GABAergic synapse density but not synapse distribution during Manduca postembryonic motoneuron development. Duch C, Levine RB (2002) Changes of calcium signaling during postembryonic dendritic growth in Manduca sexta. However, the mechanisms and cellular targets of TA modulation of locomotor activity are incompletely understood. Physiology, UM Mainz: Amparo Acker-Palmer Cell Biology, GU Frankfurt: Eva-Maria Albers Dept. Alles zur Johannes-Gutenberg-Universität Mainz und ihren 204 Studiengängen. Burkert P, Duch C (2006) Developmental changes of CaMKII localization, activity and function during postembryonic CNS remodeling in Manduca sexta. J Comp Physiol A 184:489-499. Libersat F, Duch C (2002) Morphometric analysis of dendritic remodeling in an identified motoneuron during postembryonic development. Advising by appointment only. Biozentrum 1 Hanns-Dieter-Hüsch-Weg 15, 2nd Floor, Room 02.356 D 55128 Mainz Mo. eNeuro. J Neurosci Methods 15:168(1):64-70. Acta Biol Hung 51:343-348. Toplinks. Mol. Ryglewski S, Pflueger HJ, Duch C (2007) Expanding the Neuron’s Calcium Signaling Repertoire: Intracellular Calcium Release via Voltage induced PLC and IP3R Activation. Pflueger HJ, Duch C (2011) Dynamic neural control of insect muscle metabolism related to motor behavior. Hutchinson K, Vonhoff F, Duch C (2014) Dscam1 is required for normal dendrite growth and branching but not for dendritic spacing in Drosophila motoneurons. The biogenic amines octopamine (OA) and tyramine (TA) modulate insect motor behavior in an antagonistic manner. Mol Neurobiol 29:303-320. Schützler N, Girwert C, Hügli I, Mohana G, Roignant JY, Ryglewski S*, Duch C* (2019) Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust Drosophila locomotion to nutritional state. Johannes Gutenberg University Mainz was originally founded in 1477 and today still strives to emulate the innovational spirit of its namesake. Group (private) – Master of Education, Uni Mainz. J Physiol J Physiol 590(Pt 4):809-25. Bayline RJ, Duch C, Levine RB (2001) Nerve-muscle interactions regulate motor terminal growth and myoblast distribution during muscle development. Herrera-Valdez MA, McKiernan EC*, Berger SD*, Ryglewski S, Duch C, Crook S (2013) Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron. Dutta S, Rieche F, Eckl N, Duch C, Kretzschmar D (2015) Glial expression of Swiss-Cheese, the Drosophila orthologue of Neuropathy Target Esterase, is required for neuronal ensheathment and function. eNeuro. E-mail: sac@unieducar.org.br Fone: 0800.005.3005 Escritório em São Paulo - SP: Av. European J Neurosci 17:1-18. Ryglewski S, Duch C (2012) Preparation of Drosophila Central Neurons for in situ Patch Clamping. Hotline +49 6131 39-22122. PNAS 116(9):3805-3810. awiercze@students.uni-mainz.de, anna.wierczeiko@lir-mainz.de. doi: 10.1523/ENEURO.0181-19.2019. Inst. Includes free vocabulary trainer, verb tables and pronunciation function. University Information Security and Privacy © 2020 The Arizona Board of Regents on behalf of The University of Arizona.The University of Arizona. - Fr. Neuron 93(3):632-645.e6. Front Syst Neurosci. Here we genetically remove dendrites in Drosophila motoneurons, followed by analysis of functional outcomes. ℹ️ mail.uni-mainz.de receives about 38,037 unique visitors per day, and it is ranked 25,698 in the world. Stefanie Ryglewski, Ph.D., ryglewsk@uni-mainz.de. Duch C (2006) Form and function of identified insect motoneurons. Look up the English to German translation of uni Mainz in the PONS online dictionary. Baudoux S, Duch C, Morris OT (1998) Coupling of efferent neuromodulatory neurons to rhythmical leg motor activity in the locust. Each neuron must acquire a specific ‘Gestalt’ and a defined set of ion channels during development and maintain them within critical ranges throughout life. J Physiol 593(22):4871-88. Ryglewski S, Lance K, Levine RB, Duch C (2012) Cav2 Channels Mediate LVA and HVA Calcium Currents in Drosophila Motoneurons. University Information Security and Privacy © 2020 The Arizona Board of Regents on behalf of The University of Arizona.The University of Arizona. Schmitt S, Evers JF, Scholz M, Duch C, Obermayer K (2004) New methods for the computer assisted 3D reconstruction of neurons from confocal image stacks. 2. Pathobiochem., UM Mainz: Carsten Duch Inst. OA generally enhances locomotor behaviors such as Drosophila larval crawling and flight, whereas TA decreases locomotor activity. J Comp Physiol 195(5):473-89. With approximately 32,000 students (2018) in about 100 schools and clinics, it is among the largest universities in Germany. Disease Models & Mechanisms, Dec 3 [Epub ahead of print]. Group (open) – Master Erziehungswissenschaft, Uni Mainz. Uni Mainz. Corresponding author C. Duch: Institute of Neurobiology, Johannes Gutenberg University of Mainz, Col.‐ Kleinmann Weg 2, 55099 Mainz, Germany. www.uni-mainz.de. Vonhoff F, Kühn C, Blumenstock S°, Sanyal S, Duch C (2013) A precise temporal coherency between receptor expression, neural activity, and AP-1 dependent transcription regulates dendrite development in an identified Drosophila motoneuron. Ryglewski S, Kilo L, Duch C (2014) Sequential acquisition of cacophony calcium currents, sodium channels and voltage-dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron Eur J Neurosci, 39(10):1572-85. * Shared last author. Logo der Johannes Gutenberg-Universität Mainz, Zusätzliche Informationen zu dieser Seite. Duch C, Bayline RJ, Levine RB (2000) Development of the DLM flight motor system in Manduca sexta. Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany cduch@uni-mainz.de. Ryglewski S, Duch C (2009) Shaker and Shal mediate transient calcium-independent potassium current in a Drosophila flight motoneuron. Mainz é uma cidade independente ( kreisfreie Stadt ) ou distrito urbano ( Stadtkreis ), ou seja, possui estatuto de distrito ( … Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. University Medical Center Mainz | 2,450 followers on LinkedIn. Nove de Julho, 5229 - 5° Andar J Comp Physiol A: 196(1):37-50. Kadas D, Duch C, Consoulas C. (2019) Postnatal Increases in Axonal Conduction Velocity of an Identified Drosophila Interneuron Require Fast Sodium, L-Type Calcium and Shaker Potassium Channels. Raum 01-230 (Gebäude Recht und Wirtschaft I) Tel. The University of Mainz (full name Johannes Gutenberg University Mainz) (German: Johannes Gutenberg-Universität Mainz) is a public research university in Mainz, Rhineland Palatinate, Germany, named after the printer Johannes Gutenberg since 1946.